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Analyzing effects of vaccines
1Stockholm University, Sweden.
Mathematical Biosciences
|December 1, 1991
Abstract:
A population with (individually) varying susceptibilities to infection and a vaccine with (individually) varying protective effect are considered. A simple stochastic model is used to illustrate different effects of the vaccine on the spread of the infection. The behavior of different estimators of the vaccine efficacy using data from a clinical trial and the relation between vaccine efficacy and the effectiveness of a vaccination program are discussed.