Related Experiment Video

Updated: Jul 9, 2026

Cannula Implantation into the Cisterna Magna of Rodents
10:13

Cannula Implantation into the Cisterna Magna of Rodents

Published on: May 23, 2018

A comparative study of treatment for brain edema: magnesium sulphate versus dexamethasone sodium phosphate

Omer Faruk Turkoglu1, Hakan Eroglu, Ozerk Okutan

  • 1Department of Neurosurgery, Ankara Numune Education and Research Hospital, Sihhiye, Ankara, Turkey. ofturkoglu@yahoo.com

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|December 7, 2007
PubMed

Related Concept Videos

Cerebral Edema l: Introduction01:19

Cerebral Edema l: Introduction

Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Cytotoxic Edema: Pathophysiology01:21

Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...