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Updated: Jul 9, 2026
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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
The hamster model of sequential oral oncogenesis
E Vairaktaris1, S Spyridonidou, V Papakosta
1Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Kifissias and Perikleous Stavrou 9, Athens 11521, Greece. lvairakt@med.uoa.gr
Oral Oncology
|December 7, 2007
Summary
This study used a hamster model to investigate oral cancer development. Key molecular changes, including increased cell proliferation and specific receptor expressions, were identified in early stages, suggesting potential prognostic markers for oral squamous cell carcinoma (OSCC).
Area of Science:
- Oncology
- Molecular Biology
- Carcinogenesis Research
Background:
- Oral squamous cell carcinoma (OSCC) has a low survival rate, necessitating better understanding of its development.
- Genetic alterations in oncogenes and tumor suppressor genes drive oral carcinogenesis.
- Reliable animal models are crucial for studying human oral cancer progression.
Purpose of the Study:
- To establish a chemically induced oral carcinogenesis model in Syrian golden hamsters.
- To investigate molecular changes across sequential stages of oral tumor formation.
- To identify potential early prognostic factors for OSCC progression.
Main Methods:
- Chemically induced oral carcinogenesis in Syrian golden hamsters.
- Analysis of gene and protein expression (oncogenes, apoptosis markers, tumor suppressor genes, proliferation markers) at different tumor stages.
- Correlation of molecular changes with histological progression from normal mucosa to OSCC.
Main Results:
- Early stages of oral oncogenesis showed increased apoptosis and cell proliferation.
- Upregulation of transmembrane receptors (EGFR, erbB2, FGFR-2, FGFR-3) and nuclear factors observed in early oral cancer.
- H-ras and N-ras expression did not appear to significantly impact signal transduction in this model.
Conclusions:
- The hamster cheek pouch model effectively mimics human oral cancer development stages.
- Specific molecular markers, including transmembrane receptors, may serve as early prognostic indicators for OSCC.
- Alternative signaling pathways like PI3K and/or PLCgamma might be involved in OSCC pathogenesis.
