Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiological aspects of memory B-cell development.

Sandrine Roulland1, Felipe Suarez, Olivier Hermine

  • 1Centre d'Immunologie de Marseille-Luminy (CIML), Université de la Méditerranée, 13288 Marseille, France.

Trends in Immunology
|December 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ALLOPLUS: allogeneic hematopoietic stem cell transplantation in children and adult people living with human immunodeficiency virus, a retrospective study of the SFGM-TC.

Bone marrow transplantation·2026
Same author

Cryptosporidiosis in Ptients with Inborn Errors of Immunity: Retrospective cohort study of the French National Reference Center (CEREDIH).

The Journal of infectious diseases·2026
Same author

Expanding the clinical spectrum of RNU4ATAC-opathies: more frequent and diverse than assumed.

Genetics in medicine : official journal of the American College of Medical Genetics·2026
Same author

The IL-10/IL-6 Ratio and the Risk Score: Two Cytokines-Based Predictors for Malignancy-Associated Hemophagocytic Lymphohistiocytosis in Adults (M-HLHa).

American journal of hematology·2026
Same author

Nationwide Centralized Manufacturing and Fresh Distribution of TCRαβ/CD19-DepletedGrafts: A Real-World French Experience.

Transplantation and cellular therapy·2026
Same author

Hematopoietic stem cell transplantation following invasive mold infection in chronic granulomatous disease: Insights from a case series and literature review.

Journal of human immunity·2026
Same journal

IL-33 scripts cancer immunity.

Trends in immunology·2026
Same journal

Mitochondrial Ca<sup>2+</sup> signaling: A metabolic rheostat defining tumor and immune cell fate.

Trends in immunology·2026
Same journal

Cross-priming underlies the efficacy of antibody-drug conjugates and immunotherapy combinations.

Trends in immunology·2026
Same journal

Gut microbiome metabolites meet immunometabolism in inflammatory bowel disease.

Trends in immunology·2026
Same journal

Metabolic regulatory nodes of the inflammasome and inflammatory cell death.

Trends in immunology·2026
Same journal

Parental leave in immunology - 6.

Trends in immunology·2026
See all related articles

B cells develop via two pathways: germinal center (GC) T-dependent for high-affinity responses and marginal zone (MZ) T-independent for innate-like defense. Understanding these B cell pathways aids lymphoma research.

Area of Science:

  • Immunology
  • Cell Biology
  • Oncology

Background:

  • B cells differentiate through distinct pathways: T-dependent germinal center (GC) and T-independent marginal zone (MZ).
  • GC B cells mediate slow, high-affinity responses, while MZ B cells provide rapid, innate-like immunity.
  • Follicular lymphoma (FL) and MZ lymphoma (MZL) originate from GC and MZ B cells, respectively.

Purpose of the Study:

  • To explore the functional mechanisms of GC and MZ B cells.
  • To investigate the pathological relevance of these B cell subsets in lymphomagenesis.
  • To identify therapeutic strategies for B-cell lymphomas based on normal B cell biology.

Main Methods:

  • Comparative analysis of GC and MZ B cell development and function.
  • Examination of B cell lymphoma origins and characteristics.

Related Experiment Videos

  • Integration of B cell biology with lymphoma pathogenesis.

    • Main Results:

    • GC and MZ B cells represent distinct developmental and functional lineages.
    • FL and MZL are linked to specific B cell subsets, highlighting distinct lymphomagenesis concepts.
    • Protracted preclinical antigen-driven lymphoproliferation is a key feature.

    Conclusions:

    • Understanding normal B cell pathways is crucial for deciphering lymphoma development.
    • Insights into GC and MZ B cell biology offer new avenues for lymphoma treatment design.
    • Targeting specific B cell pathways may lead to more effective therapies for follicular and MZ lymphomas.