Related Experiment Video
Updated: Jul 9, 2026

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi
Published on: July 6, 2016
Vaginal yeast adherence to the combined contraceptive vaginal ring (CCVR)
Daiane Pereira Camacho1, Márcia E L Consolaro, Eliana Valéria Patussi
1Department of Clinical Analysis, Division of Medical Mycology, Teaching and Research in Clinical Analysis Laboratory, State University of Maringá, 87020-900 Paraná, Brazil.
Background:
The purpose of this study was to evaluate the in vitro adherence of different yeasts, isolated from vaginal exudates of patients with vulvovaginal candidiasis (VVC), to the combined contraceptive vaginal ring--NuvaRing.
Study Design:
Four isolates of Candida sp. and one isolate of Saccharomyces cerevisiae were used. Adherence assays were carried out through colony-forming units per milliliter (CFU/mL), radiolabeled quantification and scanning electron microscopy (SEM) of the ring, and the cell surface hydrophobicity (CSH) of the yeasts was determined.
Results:
All the yeasts were capable of adhering to the vaginal ring, as determined by CFU/mL and in the radiolabeled assay. CSH was compatible with the adherence by CFU/mL.
Conclusion:
SEM proved the adhesion, which was different between Candida albicans and C. tropicalis. The adherence of the tested yeasts to the ring could potentially facilitate the development of VVC and recurrent VVC in susceptible patients using this contraceptive method.
Related Concept Videos
Candidiasis
Vagina
Birth Control Methods
Antifungal Agents
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Sexually Transmitted Infections
