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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Acute renal failure in horses.
1Middleburg Agricultural Research and Extension (MARE) Center, College of Agriculture and Life Sciences, Virginia Tech, 5527 Sullivans Mill Road, Middleburg, VA 20117, USA. rgeor@vt.edu
The Veterinary Clinics of North America. Equine Practice
|December 7, 2007
Summary
Acute renal failure in horses often stems from blood flow issues or toxins. Current treatment focuses on supportive care, correcting imbalances, and addressing the root cause, with dopamine and mannitol no longer advised.
Area of Science:
- Veterinary Medicine
- Equine Health
- Nephrology
Background:
- Acute renal failure (ARF) in horses is a significant clinical concern.
- Causes are typically prerenal (e.g., hemodynamic insults) or renal (e.g., nephrotoxic insults).
- Effective management strategies are crucial for improving patient outcomes.
Purpose of the Study:
- To summarize current understanding and clinical management of acute renal failure in horses.
- To highlight the importance of supportive care and addressing underlying causes.
- To update recommendations regarding specific pharmacological interventions.
Main Methods:
- Review of current veterinary literature on equine acute renal failure.
- Analysis of established and emerging treatment protocols.
- Synthesis of expert opinion on diagnostic and therapeutic approaches.
Main Results:
- Acute renal failure in horses is commonly linked to hemodynamic or nephrotoxic factors.
- Primary management involves supportive care, including fluid therapy and correction of metabolic disturbances.
- The use of dopamine and mannitol for enhancing renal blood flow and urine output is no longer recommended.
Conclusions:
- Supportive care is the cornerstone of managing equine acute renal failure.
- Identifying and reversing the underlying cause is critical for successful treatment.
- Veterinarians should avoid using dopamine and mannitol in ARF cases due to lack of efficacy and potential harm.
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