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Related Concept Videos

Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

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Related Experiment Video

Updated: Jul 9, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Chronic renal failure in horses.

Harold C Schott1

  • 1Department of Large Animal Clinical Sciences, College of Veterinary Medicine, D-202 Veterinary Medical Center, Michigan State University, East Lansing, MI 48824-1314, USA. schott@cvm.msu.edu

The Veterinary Clinics of North America. Equine Practice
|December 7, 2007
PubMed
Summary

This article discusses chronic renal failure in horses, detailing its prevalence, causes, and clinical signs. Early detection allows for short-term management, enabling continued use until the condition progresses.

Related Experiment Videos

Last Updated: Jul 9, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Area of Science:

  • Veterinary Medicine
  • Equine Health
  • Nephrology

Background:

  • Chronic renal failure (CRF) is a progressive decline in kidney function.
  • CRF in horses leads to metabolic imbalances and hormonal dysfunction.
  • Understanding CRF is crucial for equine welfare and management.

Purpose of the Study:

  • To provide a comprehensive overview of chronic renal failure in horses.
  • To outline the prevalence, causes, clinical signs, diagnostics, and management strategies for equine CRF.
  • To emphasize the importance of early detection for successful short-term management.

Main Methods:

  • Literature review and synthesis of current knowledge on equine chronic renal failure.
  • Description of diagnostic approaches for identifying CRF in horses.
  • Discussion of therapeutic and management strategies for affected horses.

Main Results:

  • Chronic renal failure is characterized by progressive loss of kidney function.
  • Clinical signs, diagnostic evaluation, and management protocols for equine CRF are detailed.
  • Successful short-term management is possible with early disease detection.

Conclusions:

  • Early diagnosis of chronic renal failure in horses allows for effective short-term management.
  • Management aims to maintain quality of life for a period, balancing productivity and welfare.
  • Euthanasia is considered when the horse's condition deteriorates beyond manageable limits.