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[Isoprenoide pathway and cell proliferation in the yeast Saccharomyces cerevisiae]
L Blanchard1, C Chambon, C Marcireau
1Laboratoire de Biochimie et Génétique des Microorganismes, Université de Poitiers, France.
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1991
Abstract:
Yeast mutants blocked in farnesyl diphosphate (FPP) synthetase have been isolated. Their specific phenotype is likely linked to a lowering in the FPP pool required for protein prenylation. The structural gene of FPP synthetase has been isolated. Complete inactivation of FPP synthetase by gene disruption is letal for the yeast cells.