Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Programmed cell death.

Barbara Conradt1, Ding Xue

  • 1Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA. barbara.conradt@dartmouth.edu

Wormbook : the Online Review of C. Elegans Biology
|December 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resveratrol isomers with opposing activities target endonuclease G to modulate neurodegeneration and mitochondrial elimination.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Cathepsin B protease mediates high population density-induced mutagenesis to drive genome evolution and competitive growth.

Nature communications·2026
Same author

Tagging of C. elegans apoptosis activator EGL-1 BH3-only reveals CED-9 BCL-2-dependent mitochondrial localization and dynamic control of EGL-1 synthesis and degradation in vivo.

Cell death and differentiation·2026
Same author

Cysteine protease cathepsin B promotes high population density-induced mutagenesis, driving genome evolution and competitive growth in response to the crowding stress.

bioRxiv : the preprint server for biology·2026
Same author

Fluorescent protein tagging of C. elegans core apoptosis pathway components reveals mitochondrial localization of CED-9 Bcl-2, CED-4 Apaf1 and CED-3 Caspase in non-apoptotic and apoptotic cells.

Cell death and differentiation·2025
Same author

Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo.

Nature communications·2025
Same journal

Caenorhabditis nomenclature.

WormBook : the online review of C. elegans biology·2018
Same journal

Tubulins in C. elegans.

WormBook : the online review of C. elegans biology·2018
Same journal

History of research on C. elegans and other free-living nematodes as model organisms.

WormBook : the online review of C. elegans biology·2017
Same journal

Development, structure, and maintenance of C. elegans body wall muscle.

WormBook : the online review of C. elegans biology·2016
Same journal

Working with dauer larvae.

WormBook : the online review of C. elegans biology·2016
Same journal

Small GTPases.

WormBook : the online review of C. elegans biology·2016
See all related articles

Programmed cell death in C. elegans development is regulated by genetic and molecular pathways. These studies identify key genes and protein cascades controlling cell death specification, activation, and removal in multicellular organisms.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • Programmed cell death is essential for development in organisms like C. elegans.
  • Over two dozen genes regulate cell death processes, including specification, activation, and removal.

Purpose of the Study:

  • To elucidate the conserved molecular and biochemical mechanisms governing the three phases of programmed cell death.
  • To detail the genetic and protein interaction cascades involved in C. elegans cell death.

Main Methods:

  • Genetic studies to identify key regulatory genes.
  • Molecular and biochemical analyses to understand protein interactions and signaling pathways.

Main Results:

  • Identified transcriptional regulators (CES-1, CES-2, HLH-1/HLH-2, TRA-1) activating egl-1.

Related Experiment Videos

  • Described a protein cascade (EGL-1, CED-9, CED-4, CED-3) activating the CED-3 protease.
  • Detailed the roles of mitochondrial factors (CPS-6, WAH-1) and nucleases (NUC-1, CRNs) in cell disassembly.
  • Characterized two redundant pathways (CED-1/6/7 and CED-2/5/10/12/PSR-1) for dying cell recognition and removal.

    • Conclusions:

    • The study provides a comprehensive overview of programmed cell death regulation in C. elegans.
    • Understanding these conserved mechanisms advances knowledge of cell death in multicellular organisms.