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Anorganic bone matrix retrieved 14 years after a sinus augmentation procedure: a histologic and histomorphometric
Giovanna Iezzi1, Marco Degidi, Antonio Scarano
1Dental School, University of Chieti-Pescara, Chieti, Italy.
Journal of Periodontology
|December 7, 2007
Summary
Anorganic bone matrix (ABM) demonstrated slow resorption over 14 years in sinus augmentation. It effectively formed vital, mature bone with no adverse effects, indicating its suitability as a graft material.
Area of Science:
- Biomaterials Science
- Oral and Maxillofacial Surgery
- Regenerative Medicine
Background:
- Anorganic bone matrix (ABM) exhibits osteoconductive properties and is generally well-tolerated in sinus augmentation.
- Histologic evidence suggests ABM resorption is slow, with limited long-term human data available.
- This case report investigates the long-term bone response to ABM in human maxillary sinus augmentation.
Purpose of the Study:
- To evaluate the bone response and material resorption of anorganic bone matrix (ABM) after 14 years.
- To assess the histologic and histomorphometric characteristics of bone formed in a maxillary sinus augmented with ABM.
Main Methods:
- Dental implants were placed in two sinuses augmented with ABM and loaded for 14 years.
- A bone core biopsy was harvested from the augmented sinus during implant removal for analysis.
Main Results:
- Histomorphometry revealed 71.0% mature bone, 22.1% residual ABM, and 11.2% marrow spaces.
- Mature, compact bone formation was observed, with some lamellar bone in contact with residual ABM particles.
- Residual ABM particles were surrounded by marrow spaces, indicating slow resorption and integration.
Conclusions:
- Anorganic bone matrix (ABM) exhibits very slow resorption, with minimal residual material after 14 years.
- ABM is an effective material for sinus augmentation, promoting the formation and maintenance of vital, mature bone.
- No chronic inflammation or adverse foreign body responses were observed, supporting ABM's long-term biocompatibility.
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