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Related Experiment Videos

PLEDs: clinical correlates.

W Fitzpatrick1, N Lowry

  • 1Department of Medicine, Division of Neurology, University of Saskatchewan, Saskatoon, SK, Canada.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|December 8, 2007
PubMed
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Periodic lateralized epileptiform discharges (PLEDs) have diverse causes, including stroke, tumors, and infections. Despite advances, PLEDs remain associated with high morbidity and mortality, particularly in severe forms like BiPLEDs Plus.

Area of Science:

  • Neurology
  • Clinical Neurophysiology

Background:

  • Periodic lateralized epileptiform discharges (PLEDs) are EEG patterns often associated with acute brain injury.
  • Understanding the diverse etiologies and outcomes of PLEDs is crucial for patient management.

Purpose of the Study:

  • To review the experience with 96 patients exhibiting PLEDs on EEG.
  • To identify the range of etiologies and associated clinical outcomes, including mortality.

Main Methods:

  • Retrospective review of EEG reports from 1999-2006 for PLEDs.
  • Analysis of patient charts, neuroimaging, and other investigations for identified cases.

Main Results:

  • Common PLED etiologies included acute stroke (26%), tumors (12%), CNS infections (12%), hemorrhage (6%), and TBI (6%).

Related Experiment Videos

  • Less common causes identified were PRES, familial hemiplegic migraine, cerebral amyloidosis, alcohol withdrawal, and chronic PLEDs from cortical dysplasia.
  • Seizure activity was present in 85% of patients; mortality was 27% overall, and 52% for BiPLEDs.

    • Conclusions:

    • PLEDs present with a broad spectrum of underlying causes.
    • Morbidity and mortality associated with PLEDs have remained largely unchanged over four decades, despite advancements in neurocritical care.