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Related Concept Videos

Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
Recombinant DNA01:09

Recombinant DNA

Overview
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...

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Related Experiment Video

Updated: Jul 9, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
11:17

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

[Therapy with recombinant growth hormone].

Martin Wabitsch1

  • 1Sektion Pädiatrische Endokrinologie, Universitätsklinik für Kinder- und Jugendmedizin, Ulm. martin.wabitsch@uniklinik-ulm.de

MMW Fortschritte Der Medizin
|December 8, 2007
PubMed
Summary

Recombinant growth hormone therapy is approved for several conditions but is expensive. Biosimilars offer a lower-cost alternative, with ongoing research evaluating their efficacy and safety for current and potential new uses.

Area of Science:

  • Endocrinology
  • Pharmacology

Context:

  • Recombinant human growth hormone (rhGH) therapy is established for growth hormone deficiency, Turner syndrome, chronic renal failure, small for gestational age (SGA), and Prader-Willi syndrome.
  • Emerging clinical data suggest potential applications in obesity, type 2 diabetes, and Crohn's disease.

Purpose:

  • To review the current approved indications for rhGH therapy.
  • To explore the potential for expanded therapeutic applications of rhGH.
  • To address the cost implications of rhGH therapy and the emergence of biosimilars.

Summary:

  • Current rhGH therapy is approved for specific pediatric and endocrine conditions.
  • Ongoing studies indicate potential benefits in metabolic and inflammatory diseases.
  • The high cost of rhGH is a barrier, prompting the development of more affordable biosimilar versions.

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Related Experiment Videos

Last Updated: Jul 9, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
11:17

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations
05:04

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations

Published on: February 2, 2024

Impact:

  • Biosimilars present a cost-effective option for rhGH therapy.
  • Further research is crucial to establish the non-inferiority of biosimilars in terms of efficacy and safety.
  • The availability of biosimilars may broaden access to growth hormone treatment and facilitate exploration of new indications.