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Sexual dimorphism in campylobacteriosis
N J C Strachan1, R O Watson, V Novik
1School of Biological Sciences, University of Aberdeen, Cruickshank Building, Aberdeen, UK. n.strachan@abdn.ac.uk
Epidemiology and Infection
|December 8, 2007
Summary
Sexual dimorphism in infectious diseases shows higher campylobacteriosis incidence in males. This study suggests physiological factors, not behavior, contribute to this gender bias in humans and mice.
Area of Science:
- Infectious Diseases
- Immunology
- Microbiology
Background:
- Sexual dimorphism in disease incidence is frequently observed.
- Behavioral and physiological factors are proposed causes for gender bias in diseases.
- Limited data exists to support either viewpoint.
Purpose of the Study:
- To investigate the role of physiological factors in the higher incidence of campylobacteriosis in males.
- To examine gender-specific differences in infection and shedding rates of Campylobacter.
Main Methods:
- Analysis of human epidemiological data on campylobacteriosis incidence across different countries and continents.
- Infection and shedding rate assessment in a male mouse model.
Main Results:
- Campylobacteriosis incidence is higher in males across diverse human populations, including infants where behavioral differences are minimal.
- Male mice exhibit increased infection and shedding rates of Campylobacter compared to females.
Conclusions:
- Physiological factors likely play a significant role in the observed male predominance in campylobacteriosis.
- The findings support a biological basis for gender bias in this infectious disease, independent of behavioral influences.
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