Hormonal treatment of male infertility: FSH

FSH plays a crucial role in spermatogenesis. In the fetal and neonatal development stages, FSH activates the proliferation of the Sertoli cells and successively, during the pubertal phase, it influences the mitotic activity of the spermatogonia and encourages cellular differentiation, until arrival at the round spermatid stage. Because of its physiological role in spermatogenesis, various attempts have been made to treat idiopathic oligozoospermic men with FSH. However, the results obtained so far are still controversial. In this research, attention was focused on the possible criteria able to predict a seminal response to this specific hormonal treatment. Furthermore, the effectiveness of FSH therapy was evaluated in terms of sperm count and pregnancy rate. Thus far, based on more recent knowledge about the FSH receptor gene, the authors have correlated different polymorphisms of this gene with the outcome of FSH treatment. In this paper, the literature is reviewed and the authors' experience on using FSH in male infertility is discussed.