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Pigmented nail with atypical melanocytic hyperplasia
1Department of Dermatology, Seoul National University College of Medicine, Korea.
Clinical and Experimental Dermatology
|November 1, 1991
Summary
Diagnosing nail melanoma is challenging. Two cases of acral lentiginous melanoma (ALM) in situ showed epidermal atypical melanocytic hyperplasia, even with long-standing lesions.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Pigmented subungual lesions have a higher likelihood of malignancy.
- Early diagnosis of subungual melanoma, particularly during the radial-growth phase, presents significant clinical challenges.
Observation:
- Two cases of black nail discoloration were examined.
- Histological analysis confirmed acral lentiginous melanoma (ALM) in situ in both cases.
Findings:
- Atypical melanocytic hyperplasia was confined to the epidermis.
- This epidermal confinement occurred despite the lesions being present for an extended duration.
Implications:
- Highlights the diagnostic difficulty of subungual melanoma.
- Suggests that ALM in situ may exhibit atypical melanocytic hyperplasia limited to the epidermis, even in long-standing cases.
- Emphasizes the need for vigilant monitoring and thorough histopathological examination of pigmented subungual lesions.