Related Experiment Video
Updated: Jul 9, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus
Published on: October 11, 2013
New 1-indanone thiosemicarbazone derivatives active against BVDV
Liliana M Finkielsztein1, Eliana F Castro, Lucas E Fabián
1Cátedra de Química Orgánica III, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113), Ciudad Autónoma de Buenos Aires, Argentina.
Abstract:
Identification of new therapeutic agents for the treatment of viral diseases represents an area of active investigation. In an effort to develop new antiviral compounds, a series of 1-indanone thiosemicarbazone derivatives were synthesized. These derivatives were structurally characterized using several spectroscopic techniques and evaluated against bovine viral diarrhoea virus as a surrogate model for hepatitis C virus. Thiosemicarbazone 2m showed potent anti-bovine viral diarrhoea virus activity with a higher selectivity index (SI=80.29) than that of ribavirin (SI=11.64). This result determines the potentiality of these thiosemicarbazones as antiviral agents for the treatment of infections caused by other highly related members of Flaviviridae family, as hepatitis C virus.
Related Concept Videos
Antiviral Nucleoside Inhibitors
Inhibitors Of Virion Release
Inhibitors of Virion Maturation and Assembly
Inhibitors of Bacterial DNA Synthesis
Inhibitors of Viral Protein Synthesis
Subviral Agents
