[Experimental and clinical study of activated platelet in allergic asthma]

Twenty-five asthmatic Guinea pigs and fourteen asthmatic patients were included in this study. The results showed that the plasma concentration of lyso platelet activating-factor (lyso-PAF), B-thromboglobulin (B-TG), platelet factor 4 (PF4), TXB2, the ratio of TXB2/6-keto-PGF1a and the platelet aggregation rate (PAgT) were significantly increased (P less than 0.01) during acute attack, but the platelet count and plasma level of 6-keto-PGF1a were markedly decreased (P less than 0.01). During remission, the function of platelet gradually returned to normal. BN 52021 inhibited platelet aggregation and secretion and relieved the symptoms in seven asthmatic guinea pigs. We suggest that platelet may play an important role in allergic asthma and antiplatelet drugs may be used for prophylaxis and treatment.