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Related Experiment Videos

Clostridium difficile.

Mallori Hooker1

  • 1Rocky Mountain Cancer Center, Denver, CO, USA. mallori.hooker@usoncology.com

Clinical Journal of Oncology Nursing
|December 8, 2007
PubMed
Summary
This summary is machine-generated.

A patient with myelofibrosis developed Clostridium difficile infection after a stem cell transplant, complicated by graft-versus-host disease. Prompt treatment with metronidazole was initiated for the C. difficile diagnosis.

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Area of Science:

  • Hematology
  • Gastroenterology
  • Infectious Disease

Background:

  • Allogeneic stem cell transplantation is a curative option for myelofibrosis.
  • Graft-versus-host disease (GVHD) is a common complication following allogeneic stem cell transplantation.
  • Patients undergoing transplantation are immunocompromised, increasing susceptibility to infections.

Observation:

  • A 55-year-old male with myelofibrosis presented with symptoms suggestive of gut GVHD post-transplant.
  • The patient was on immunosuppressive therapy including tacrolimus and corticosteroids.
  • A stool sample confirmed Clostridium difficile toxin A positivity.

Findings:

  • The patient was diagnosed with Clostridium difficile infection concurrently with a potential GVHD flare.

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  • Oral metronidazole was administered for the treatment of Clostridium difficile infection.
  • This case highlights the potential for opportunistic infections in transplant recipients.

    • Implications:

    • Early recognition and treatment of Clostridium difficile infection are crucial in immunocompromised patients.
    • Distinguishing between GVHD and infectious colitis can be challenging in stem cell transplant recipients.
    • This case underscores the importance of vigilant monitoring for infections post-transplantation.