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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

33.4K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
27.3K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Stem Cell Culture01:17

Stem Cell Culture

6.1K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Related Experiment Video

Updated: Jan 26, 2026

A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells
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Stem cells tropism for malignant gliomas.

Feng Xu1, Jian-Hong Zhu

  • 1Department of Neurosurgery, Shanghai Neurosurgical Center, Huashan Hospital of Fudan University, Shanghai 200040, China.

Neuroscience Bulletin
|December 8, 2007
PubMed
Summary

Stem cells show strong tropism for malignant gliomas, offering potential for gene therapy delivery. This review explores the underlying mechanisms, focusing on soluble factors released by glioma cells.

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Neuroscience

Background:

  • Malignant gliomas are aggressive brain tumors.
  • Stem cells exhibit remarkable tropism towards glioma cells.
  • This tropism suggests potential for targeted cancer therapies.

Purpose of the Study:

  • To review and elucidate the mechanisms behind stem cell tropism for malignant gliomas.
  • To understand how glioma cells attract stem cells.
  • To identify potential therapeutic strategies based on these mechanisms.

Main Methods:

  • Literature review of existing studies on stem cell-glioma interactions.
  • Analysis of research on soluble factors mediating cell-cell communication.
  • Synthesis of findings regarding chemokine and growth factor involvement.

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Main Results:

  • Stem cell tropism for gliomas is a well-documented phenomenon.
  • Soluble factors, including chemokines and growth factors, secreted by glioma cells are key mediators.
  • These factors likely orchestrate the migration and homing of stem cells to tumor sites.

Conclusions:

  • Understanding the mechanisms of stem cell tropism is crucial for developing effective glioma gene therapies.
  • Targeting glioma-secreted soluble factors could enhance stem cell-mediated drug delivery.
  • Further research into these mechanisms will pave the way for novel therapeutic approaches.