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Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection
Published on: December 30, 2025
Hypercoagulability after partial liver resection
Annie Bezeaud1, Marie Hélène Denninger, Federica Dondero
1Service d'Hématologie Biologique, Hôpital Beaujon, APHP, 100, Boulevard du Général Leclerc, 92118 CLICHY Cedex, France. annie.bezeaud@bjn.aphp.fr
Thrombosis and Haemostasis
|December 8, 2007
Summary
Post-liver resection surgery increases thrombosis risk. Thrombin-antithrombin complexes and sP-selectin show promise as early predictors of these dangerous blood clots.
Area of Science:
- Hepatology
- Transplantation Surgery
- Hemostasis and Thrombosis
Background:
- Living donor liver transplantation carries inherent risks for donors, including postoperative thrombosis.
- Understanding coagulation changes after partial liver resection is crucial for donor safety and managing thrombotic complications.
Purpose of the Study:
- To investigate coagulation alterations following partial liver resection in living donors and control patients.
- To identify potential early biological markers for predicting postoperative thrombotic complications.
Main Methods:
- Coagulation parameters, including inhibitors (protein C, antithrombin) and procoagulant factors (factor VIII, von Willebrand factor), were measured.
- Prothrombotic markers such as thrombin-antithrombin complexes and sP-Selectin were assessed.
- Patients were compared based on the development of thrombosis (pulmonary embolism, portal vein thrombosis).
Main Results:
- An early postoperative decrease in protein C and antithrombin, with a concurrent rise in factor VIII and von Willebrand factor, was observed in all patients.
- Significantly elevated levels of thrombin-antithrombin complexes were found in patients who developed thrombosis on postoperative days 1 and 2.
- sP-Selectin levels were also significantly higher in the thrombosis group on postoperative days 2 and 4.
Conclusions:
- Partial liver resection induces significant hemostatic system dysregulation, increasing the risk of thrombosis.
- Thrombin-antithrombin complexes and sP-selectin are potential early predictive biomarkers for postoperative thrombotic events.
- Enhanced thromboprophylaxis strategies are warranted following partial liver resection procedures.
