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[Association of hyperinsulinemia with left ventricular hypertrophy and diastolic dysfunction in patients with

Ernesto Germán Cardona-Muñoz1, David Cardona-Müller, Sylvia Totsuka-Sutto

  • 1Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, México. came_1@lycos.com

Revista Medica De Chile
|December 8, 2007
PubMed

Insights

Hyperinsulinemia, characterized by high insulin levels, is linked to increased ventricular mass and diastolic dysfunction in hypertensive patients. This association persists regardless of blood pressure or age, highlighting insulin

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Hypertension Research

Context:

  • Hypertension is a primary independent risk factor for cardiovascular disease.
  • Additional factors beyond blood pressure contribute to organ damage in hypertensive individuals.
  • Hyperinsulinemia, characterized by elevated insulin levels, is increasingly recognized as a potential contributor to cardiovascular complications.

Purpose:

  • To investigate the relationship between hyperinsulinemia and cardiac structural and functional changes.
  • To assess the association between elevated insulin levels, left ventricular hypertrophy, and diastolic dysfunction in patients with hypertension.

Summary:

  • A study involving 74 hypertensive patients (aged 30-65) with normal glucose tolerance evaluated associations between insulin levels and cardiac parameters.
  • Patients were categorized into normoinsulinemic, post-prandial hyperinsulinemic, and persistently hyperinsulinemic groups based on fasting and post-glucose challenge insulin levels.
  • Results indicated a negative correlation between ventricular mass and insulin levels (rG/I), with significantly worse left ventricular diastolic dysfunction observed in persistently hyperinsulinemic individuals.

Impact:

  • Fasting and post-challenge hyperinsulinemia, particularly with an insulin resistance index (rG/I) below 1, are independently associated with increased left ventricular mass and diastolic dysfunction.
  • These findings suggest that hyperinsulinemia is a significant factor contributing to cardiac damage in hypertension, independent of blood pressure and age.
  • The study underscores the importance of considering metabolic factors like hyperinsulinemia in the comprehensive management of hypertensive cardiovascular risk.
Abstract

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