Neurotoxicity in Alzheimer's disease: is covalently crosslinked A beta responsible?
Ryan Naylor1, Andrew F Hill, Kevin J Barnham
1Department of Pathology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3010, Australia.
Abstract:
Alzheimer's disease is the most common form of dementia in the elderly, and is characterised by extracellular amyloid plaques composed of the beta-amyloid peptide (A beta). However, disease progression has been shown to correlate more closely with the level of soluble A beta oligomers. Recent evidence suggests that these oligomers are covalently crosslinked, possibly due to the interaction of A beta with redox-active metal ions. These findings offer new avenues for the treatment and prevention of disease, by modulating metal binding or preventing the formation of neurotoxic A beta oligomers.
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