Polymorphisms of human leukocyte antigen genes in korean children with Kawasaki disease

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Jin Hee Oh1, Ji Whan Han, Soon Ju Lee

  • 1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Pediatric Cardiology
|December 8, 2007
PubMed

Insights

Human leukocyte antigen (HLA) gene variations are linked to Kawasaki disease in Korean children. Specific HLA-B and HLA-C alleles increase susceptibility, while certain HLA-DRB1 alleles are associated with coronary complications.

Area of Science:

  • Immunogenetics
  • Pediatric Cardiology
  • Molecular Genetics

Background:

  • Kawasaki disease is a primary cause of acquired heart disease in children.
  • Prevalence of Kawasaki disease differs across ethnic groups.
  • Human Leukocyte Antigen (HLA) polymorphisms are increasingly linked to various diseases via DNA analysis.

Purpose of the Study:

  • To investigate the association between HLA alleles and the risk of developing Kawasaki disease in Korean children.
  • To determine if specific HLA alleles are linked to coronary complications in pediatric patients with Kawasaki disease.

Main Methods:

  • DNA was extracted from 74 children diagnosed with Kawasaki disease.
  • HLA-A, -B, -C, and -DRB1 allele polymorphisms were analyzed using PCR-ARMS and PCR-SSP.
  • Patient polymorphisms were compared against 159 healthy control subjects.

Main Results:

  • Significant increases in HLA-B35, -B75, and -Cw09 allele frequencies were observed in Kawasaki disease patients versus controls.
  • No significant increase in HLA-DRB1 allele frequency was found in Kawasaki disease patients compared to controls.
  • Kawasaki disease patients with coronary complications showed increased frequencies of HLA-DRB1*11 and HLA-DRB1*09 compared to healthy controls and subgroups.

Conclusions:

  • Polymorphisms in specific HLA class I alleles (B and C) are associated with Kawasaki disease susceptibility in Korean children.
  • Certain HLA-DRB1 alleles may be linked to the development of coronary complications in Kawasaki disease.
Abstract

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