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Colloids

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

The Colloidal State

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...

Colloidal precipitates

Colloidal precipitates

The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...

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Coagulation

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...

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Updated: Jul 9, 2026

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Magnetic colloids as drug vehicles.

J D G Durán¹, J L Arias, V Gallardo

¹Department of Applied Physics, Faculty of Sciences, University of Granada, 18071 Granada, Spain. jdgarcia@ugr.es

Journal of Pharmaceutical Sciences

|December 8, 2007

Summary

Magnetic drug delivery systems (DDS) use magnetic nanoparticles for targeted drug release. Current research focuses on particle design, stability, and in vivo behavior, with human trials still limited.

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Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

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Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Published on: October 19, 2015

Area of Science:

Biomedical Engineering
Nanotechnology
Materials Science

Background:

Magnetic drug delivery systems (DDS) are colloidal dispersions of composite nanoparticles.
These nanoparticles combine a biocompatible matrix with magnetic units for drug loading and release.
The matrix enhances colloidal stability and immune response control, while magnetic inclusions enable guidance.

Purpose of the Study:

To review the current status of magnetic drug delivery systems (DDS).
To describe the production techniques, interface aspects, and magnetic guidance capabilities of these DDS.
To discuss the fate of magnetic DDS in biological environments and their biodistribution.

Main Methods:

Review of existing literature on magnetic DDS.
Description of nanoparticle synthesis and characterization.
Analysis of in vitro and in vivo experimental data, including biodistribution studies.

Main Results:

Magnetic DDS offer controlled drug loading and release with magnetic guidance.
Interface properties are crucial due to the high surface/volume ratio of nanoparticles.
In vitro and in vivo studies show promising biodistribution, but human data is limited.

Conclusions:

Magnetic DDS represent a promising platform for targeted therapy.
Further research is needed to optimize particle design and overcome challenges for clinical translation.
Human trials are essential to validate the efficacy and safety of magnetic DDS.