Related Experiment Video

Updated: Jul 9, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

Hepatitis C virus infection in haemodialysis and kidney transplant patients

Seema Baid-Agrawal1, Manuel Pascual, Darius Moradpour

  • 1Department of Nephrology and Medical Intensive Care, Campus Virchow-Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany. seema.baid-agrawal@charite.de

Reviews in Medical Virology
|December 8, 2007
PubMed

Insights

Chronic hepatitis C virus (HCV) infection impacts survival in dialysis and kidney transplant patients. Treating HCV before transplantation is recommended, as antiviral therapy is risky post-transplant.

Area of Science:

  • Nephrology
  • Hepatology
  • Virology

Background:

  • Chronic hepatitis C virus (HCV) infection is a global health issue.
  • HCV prevalence is elevated in haemodialysis and kidney transplant recipients.
  • HCV negatively impacts survival and graft outcomes in these patient populations.

Purpose of the Study:

  • To review the impact of HCV on haemodialysis and kidney transplant patients.
  • To discuss current and evolving antiviral treatment strategies.
  • To highlight the need for further clinical trials.

Main Methods:

  • Literature review of HCV in renal disease patients.
  • Analysis of survival and graft outcomes.
  • Evaluation of antiviral therapy efficacy and safety.

Main Results:

  • HCV infection adversely affects survival in haemodialysis patients.
  • HCV negatively impacts patient and graft survival post-kidney transplantation.
  • Kidney transplantation improves survival compared to dialysis, even with HCV.
  • Interferon-based antiviral therapy poses risks post-transplantation.

Conclusions:

  • HCV infection should not preclude kidney transplantation.
  • Antiviral treatment before transplantation is the preferred strategy.
  • Further multi-center trials are essential to optimize HCV treatment in these patients.

More Related Videos

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

A Protocol for Analyzing Hepatitis C Virus Replication13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...