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Updated: Jul 9, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
[Immunological defense to viral infections: focus on virus-specific T cells]
G J de Bree1, E M M van Leeuwen, R J M ten Berge
1Afd. Inwendige Geneeskunde, Academisch Medisch Centrum/Universiteit van Amsterdam, Huispost F4-222, Meibergdreef 9, 1105 AZ Amsterdam. g.j.debree@amc.uva.nl
Abstract:
T cells play a central role in the control of and the protection against viral infections. The T cell population consists ofa diversity ofvirus-specific memory T cells. The characteristics of these T cells seem to depend largely on the type of virus for which they are specific. T cells directed against latent viruses, such as cytomegalovirus, are cytotoxic cells. T cells directed against viruses that after the initial infection are completely removed by the immune system, such as the influenza virus, are non-cytotoxic cells. The development of new immunological techniques, such as the detection of virus-specific cells with HLA-peptide tetrameric complexes, enables the characterization of the properties of virus-specific T cells in the blood and organs.
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