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Updated: Jul 9, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

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Published on: March 19, 2019

[An update on Candida dubliniensis].

A Paugam¹, M-T Baixench, C Viguié

¹Laboratoire de parasitologie-mycologie, groupe hospitalier Cochin-Saint-Vincent-de-Paul, Assistance publique-Hôpitaux de Paris, université Paris-Descartes, Paris, France. andre.paugam@cch.aphp.fr

Medecine Et Maladies Infectieuses

|December 11, 2007

Summary

This summary is machine-generated.

Candida dubliniensis, a newly identified yeast, is frequently found in oral candidiasis cases, particularly in HIV-infected individuals. While fluconazole resistance is experimentally faster in C. dubliniensis, it remains rare in clinical settings.

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Area of Science:

Mycology
Molecular Biology
Infectious Diseases

Background:

Candida dubliniensis, identified eleven years ago, is closely related to Candida albicans.
Initially found in AIDS patients with oral candidiasis, it is now detected in immunocompetent individuals.
Recent advancements in identification tests have facilitated numerous epidemiological studies.

Purpose of the Study:

To review the epidemiology and characteristics of Candida dubliniensis.
To compare the prevalence and fluconazole resistance of C. dubliniensis and C. albicans.
To highlight the clinical relevance of C. dubliniensis in various patient populations.

Main Methods:

Review of epidemiological studies utilizing new identification tests (latex, immunochromatography).
Analysis of C. dubliniensis prevalence in oral cavities of HIV-infected and non-infected patients.
Experimental comparison of fluconazole resistance acquisition between C. dubliniensis and C. albicans.

Main Results:

C. dubliniensis is predominantly identified in the oral cavity across studies.
The ratio of C. dubliniensis to C. albicans is 1-5% in non-HIV infected individuals, increasing to 15-20% in HIV-infected patients.
C. dubliniensis exhibits faster experimental acquisition of fluconazole resistance compared to C. albicans, though clinical resistance is rare.

Conclusions:

Candida dubliniensis is an emerging opportunistic fungal pathogen with increasing detection rates.
HIV infection significantly correlates with a higher prevalence of C. dubliniensis.
Despite experimental findings, clinical fluconazole resistance of C. dubliniensis remains an infrequent observation, suggesting complex resistance mechanisms in vivo.