Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct sensory and autonomic involvement in hypermobile Ehlers-Danlos syndrome compared with idiopathic small fiber neuropathy: a multimodal study.

Scientific reports·2026
Same author

Inter-centre heterogeneity, temporal evolution, and factors associated with treatment selection and outcomes in chronic inflammatory demyelinating polyradiculoneuropathy: a multicentre, combined prospective and retrospective observational study.

EClinicalMedicine·2026
Same author

Cortical correlates of apathy in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy with two different pathogenic mutations in the NOTCH3 gene.

Neuropsychology·2026
Same author

Muscle biopsy in genomic era: real-world diagnostic and clinical implications over 10 years.

Journal of neurology·2026
Same author

A Quantitative Assessment of Upper Limb Motor Function Across Disease Stages in Hereditary Transthyretin Amyloidosis.

Journal of the peripheral nervous system : JPNS·2026
Same author

Deep Phenotyping of F64L Mutation in a Multicentric Cohort of Patisiran-Treated Hereditary Transthyretin Amyloidosis Patients (Patisiranitaly).

European journal of neurology·2026

Related Experiment Video

Updated: Jul 9, 2026

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

Motor cortex cholinergic dysfunction in CADASIL: a transcranial magnetic demonstration.

Fiore Manganelli1, Michele Ragno, Gabriella Cacchiò

  • 1Department of Neurological Sciences, University Federico II of Naples, Via Sergio Pansini, 5, 80131 Naples, Italy.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|December 11, 2007
PubMed
Summary

Short latency afferent inhibition (SAI) revealed a central cholinergic deficit in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) patients. This finding suggests SAI may monitor cholinergic dysfunction and treatment efficacy in CADASIL.

More Related Videos

Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
14:47

Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning

Published on: April 21, 2023

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System
12:19

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System

Published on: January 20, 2012

Related Experiment Videos

Last Updated: Jul 9, 2026

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
14:47

Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning

Published on: April 21, 2023

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System
12:19

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System

Published on: January 20, 2012

Area of Science:

  • Neuroscience
  • Neurology
  • Genetics

Background:

  • Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a genetic small vessel disease.
  • It is characterized by early-onset cognitive decline.

Purpose of the Study:

  • To investigate cortical cholinergic innervation in CADASIL patients.
  • Utilize the short latency afferent inhibition (SAI) technique to assess cholinergic function.

Main Methods:

  • Applied SAI in ten CADASIL patients and ten age-matched controls.
  • SAI measures motor evoked potentials following transcranial magnetic stimulation and peripheral nerve input.

Main Results:

  • CADASIL patients exhibited significantly reduced SAI compared to controls (p<0.001).
  • Mean resting motor threshold was significantly lower in CADASIL patients (p=0.02).

Conclusions:

  • Demonstrated central cholinergic impairment in CADASIL using SAI.
  • SAI may serve as a biomarker for cholinergic dysfunction and cholinomimetic therapy efficacy in CADASIL.