Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Structure01:45

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parent and professional experiences of a clinical trial of prenatal and postnatal stem cell therapy for severe osteogenesis imperfecta.

European journal of human genetics : EJHG·2026
Same author

Moving beyond good intentions: a qualitative study exploring healthcare professionals' perspectives on delivering equitable prenatal testing in the English NHS.

International journal for equity in health·2026
Same author

Fetal Sequencing: Lessons Learnt and Challenges Remaining.

Prenatal diagnosis·2026
Same author

Precision Antisense Oligonucleotide Therapy Amenability for Infantile Genetic Epilepsies.

JAMA neurology·2026
Same author

Optimising rapid prenatal exome sequencing in the NHS genomic medicine service: the EXPRESS Synopsis.

Health and social care delivery research·2026
Same author

Diagnostic Yield of Sequencing for Prenatal Diagnosis of Fetal Structural Anomalies: An Updated Systematic Review.

Prenatal diagnosis·2026

Related Experiment Video

Updated: Jul 9, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Dysplastic kidneys.

Paul Winyard1, Lyn S Chitty

  • 1Institute of Child Health, University College London, 30 Guilford Street, London, UK. pwinyard@ich.ucl.ac.uk

Seminars in Fetal & Neonatal Medicine
|December 11, 2007
PubMed
Summary
This summary is machine-generated.

Dysplastic kidneys, a common congenital abnormality, require careful monitoring during pregnancy and after birth. Prognosis depends on disease extent, renal mass, obstruction, and amniotic fluid levels, necessitating a multidisciplinary approach.

More Related Videos

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition
03:19

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition

Published on: June 21, 2024

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

Related Experiment Videos

Last Updated: Jul 9, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition
03:19

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition

Published on: June 21, 2024

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

Area of Science:

  • Pediatric Nephrology
  • Medical Genetics
  • Prenatal Diagnosis

Background:

  • Dysplastic kidneys are a significant component of Congenital Abnormalities of the Kidney and Urinary Tract (CAKUT).
  • Antenatal ultrasound increasingly detects these malformations in children.
  • Historically, detection often occurred later in life or incidentally, unless severe bilateral disease caused early renal failure.

Purpose of the Study:

  • To outline the prognostic indicators for dysplastic kidneys detected prenatally.
  • To describe the dynamic nature of renal dysplasia and function during gestation.
  • To review current and future management strategies, including genetic screening.

Main Methods:

  • Review of clinical features and prognostic factors in dysplastic kidney disease.
  • Discussion of antenatal and postnatal assessment strategies.
  • Exploration of genetic underpinnings and potential screening approaches.

Main Results:

  • Key indicators for worse prognosis include bilateral disease, reduced functional renal mass, lower urinary tract obstruction, and anhydramnios/oligohydramnios.
  • Renal dysplasia and function can evolve during pregnancy, requiring repeated assessments.
  • Postnatal management involves observation, antibiotics, surgery, or renal support, with long-term monitoring for hypertension and renal function.

Conclusions:

  • Dysplastic kidneys necessitate ongoing multidisciplinary care, from prenatal diagnosis to long-term adult follow-up.
  • While no prenatal therapies exist, interventions like vesicoamniotic shunting may be considered for obstruction.
  • Genetic factors play a role, with potential for future multi-gene screening alongside clinical management.