Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

BRCA2: a universal recombinase regulator.

T Thorslund1, S C West

  • 1London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts, UK.

Oncogene
|December 11, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Practice variation in the diagnosis of acute rejection among pediatric heart transplant centers: An analysis of the pediatric heart transplant society (PHTS) registry.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2021
Same author

Cost-effectiveness of pediatric heart transplantation across a positive crossmatch for high waitlist urgency candidates.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Practical design and performance of the stressed-lap polishing tool.

Applied optics·2010
Same author

Optical metrology for two large highly aspheric telescope mirrors.

Applied optics·2010
Same author

Double-strand break repair in human cells.

Cold Spring Harbor symposia on quantitative biology·2003
Same author

Nonhomologous end joining and V(D)J recombination require an additional factor.

Proceedings of the National Academy of Sciences of the United States of America·2003
Same journal

Correction: Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway.

Oncogene·2026
Same journal

Amphiregulin-mediated EGFR activation drives both intrinsic and acquired resistance to KRAS G12C inhibitors in KRAS G12C-mutant non-small cell lung cancer.

Oncogene·2026
Same journal

Histone lactylation-driven IGF2BP3 promotes intrahepatic cholangiocarcinoma progression via SPP1/CD44-dependent macrophage polarization.

Oncogene·2026
Same journal

Correction: SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle.

Oncogene·2026
Same journal

Correction: Liver-specific SIRT1 knockout-induced hyperglycemia promotes spontaneous lung adenocarcinomas through HSF1-MDM2.

Oncogene·2026
Same journal

Correction: 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells.

Oncogene·2026
See all related articles

Homologous recombination is vital for genetic diversity and DNA repair. The BRCA2 protein, crucial for preventing cancer, acts as a universal regulator of key recombination enzymes like RAD51 and DMC1.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Homologous recombination is essential for genetic variation during meiosis and DNA double-strand break repair in mitotic cells.
  • BRCA2 protein is a tumor suppressor linked to breast and ovarian cancers; its loss causes genetic instability.
  • BRCA2 interacts with RAD51 to regulate DNA repair, and recent findings show it also interacts with DMC1 in meiosis.

Purpose of the Study:

  • To elucidate the dual role of homologous recombination in eukaryotes.
  • To investigate the function of BRCA2 in DNA repair and genetic stability.
  • To explore the interactions of BRCA2 with RAD51 and DMC1.

Main Methods:

  • The study focuses on the functional interactions of BRCA2 with RAD51 and DMC1.

Related Experiment Videos

  • It examines the role of BRCA2 in DNA double-strand break repair and meiotic recombination.
  • Analysis of genetic instability in BRCA2-defective cells.

    • Main Results:

    • BRCA2 interacts with both RAD51 and DMC1, suggesting a regulatory role in recombination.
    • Loss of BRCA2 function leads to significant genetic instability and chromosomal aberrations.
    • BRCA2 is implicated in both meiotic and mitotic homologous recombination pathways.

    Conclusions:

    • BRCA2 acts as a universal regulator of recombinase enzymes (RAD51 and DMC1).
    • The protein plays a critical role in maintaining genome integrity and preventing cancer.
    • Understanding BRCA2's function is key to developing cancer therapies.