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Related Experiment Videos

Obsessive-compulsive disorder.

M S George1

  • 1NIMH, Bethesda, MD 20892.

International Clinical Psychopharmacology
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Obsessive-compulsive disorder (OCD) affects 2% of adults with intrusive thoughts and repetitive actions. While the cause is unknown, treatments like 5HT reuptake inhibitors are effective for managing symptoms.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Obsessive-compulsive disorder (OCD) was historically misperceived as rare and untreatable.
  • Current understanding refutes earlier psychodynamic theories, recognizing OCD as a distinct neuropsychiatric syndrome.

Purpose of the Study:

  • To review the phenomenology and etiology of obsessive-compulsive disorder (OCD).
  • To emphasize current pharmacological treatments for OCD.

Main Methods:

  • Review of recent neuro-imaging studies implicating basal ganglia and frontal cortex.
  • Analysis of genetic studies linking OCD to chronic motor tics and Gilles de la Tourette Syndrome.

Main Results:

  • OCD affects approximately 2% of the adult population.

Related Experiment Videos

  • Neuro-imaging suggests basal ganglia and frontal cortex involvement in OCD pathogenesis.
  • Genetic studies indicate a significant hereditary component and links to tic disorders.

    • Conclusions:

    • OCD is a common disorder with identifiable neurobiological correlates.
    • While a cure is elusive, pharmacological interventions, particularly 5HT reuptake inhibitors, show efficacy in symptom management.