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Updated: Jul 9, 2026
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A Murine Model of Subarachnoid Hemorrhage
Published on: November 21, 2013
Temperature rhythm in aneurysmal subarachnoid hemorrhage.
Catherine J Kirkness1, Robert L Burr, Hilaire J Thompson
1Biobehavioral Nursing and Health Systems, University of Washington, 1959 NE Pacific Street, Health Sciences Building, Room T620A, Box 357266, Seattle, WA 98195-7266, USA. kirkness@u.washington.edu
Neurocritical Care
|December 11, 2007
Summary
Altered body temperature rhythms after cerebral aneurysm rupture are common and linked to worse outcomes. These temperature pattern changes offer predictive insights beyond initial neurological status.
Area of Science:
- Neurology
- Critical Care Medicine
- Physiology
Background:
- Temperature dysregulation is common after brain injury and linked to poor outcomes.
- Few studies have investigated temperature rhythms post-cerebral aneurysm rupture.
- Understanding these rhythms is crucial for managing patients.
Purpose of the Study:
- To describe diurnal temperature patterns in patients with ruptured cerebral aneurysms.
- To examine the association between temperature rhythm parameters and clinical factors.
- To assess the relationship with mortality and functional outcomes.
Main Methods:
- Cosinor analysis was used to estimate temperature mesor, amplitude, and acrophase.
- 86 patients hospitalized for acute management of cerebral aneurysms were studied.
- Associations with clinical condition, mortality, and 6-month outcomes were analyzed.
Main Results:
- Most patients had elevated temperature mesors and blunted amplitudes.
- Acrophases were widely dispersed, deviating from normative patterns.
- Altered cosinor parameters correlated with worse initial condition and poorer outcomes.
Conclusions:
- Abnormal temperature rhythm parameters predict outcomes beyond initial neurological status.
- Further research is needed to elucidate the pathophysiology of temperature dysregulation.
- Investigating temperature management strategies may improve patient outcomes.
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