Related Experiment Video
Updated: Jul 9, 2026

05:37
Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
Synthesis and characterization of tetra-end linked oligonucleotides capable of forming monomolecular G-quadruplexes
Nicola Borbone1, Giorgia Oliviero, Jussara Amato
1Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, via Domenico Montesano 49, Naples 80131, Italy. borbone@unina.it
Nucleosides, Nucleotides & Nucleic Acids
|December 11, 2007
Abstract:
The chemical synthesis of two new G-rich Tetra-End-Linked-oligodeoxyribonucleotides (TEL-ODNs) as well as (1)H-NMR and CD spectra of the corresponding monomolecular quadruplexes (IVa and IVb) has been reported. The new TEL-ODNs, characterized by the presence of short branches in the linker moiety, could be very useful for the achievement of monomolecular quadruplexes with predetermined strand orientation.

