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Updated: Jul 9, 2026
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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Efficient synthesis of benzamide riboside, a potential anticancer agent
Laurent F Bonnac1, Guang-Yao Gao, Liqiang Chen
1Center for Drug Design, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN 55455, USA.
Nucleosides, Nucleotides & Nucleic Acids
|December 11, 2007
Summary
A new five-step synthesis for benzamide riboside (BR) is now available for large-scale production. This efficient method supports further preclinical research into benzamide riboside
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
- Biochemistry
Background:
- Benzamide riboside (BR) is being investigated for its potential anticancer properties.
- Efficient synthesis is crucial for advancing the preclinical evaluation of novel therapeutic agents.
Purpose of the Study:
- To develop an efficient, scalable synthetic route for benzamide riboside (BR).
- To facilitate comprehensive preclinical studies of BR as a potential anticancer drug.
Main Methods:
- A five-step synthetic pathway was designed and optimized.
- The synthesis was demonstrated to be amenable to large-scale production.
Main Results:
- An efficient five-step synthesis of benzamide riboside was successfully developed.
- The synthetic route is suitable for large-scale manufacturing.
Conclusions:
- The developed synthesis provides a reliable method for producing benzamide riboside in quantities required for extensive preclinical testing.
- This advancement supports the continued investigation of benzamide riboside's therapeutic potential in oncology.
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