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Updated: Jul 9, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Triplex-forming ability of modified oligonucleotides
Torben Højland1, B Ravindra Babu, Torsten Bryld
1Nucleic Acid Center, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. tohoe00@student.sdu.dk
Abstract:
We present our studies on the ability of several different nucleotide analogs as triplex-forming oligonucleotides. The modifications tested include 4'-C-hydroxymethyl, LNA, 2'-amino-LNA and N2'-functionalized 2'-amino-LNA. Triplexes containing monomers of N2'-glycyl-functionalized 2'-amino-LNA are particularly stable.
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