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Updated: Jul 9, 2026

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
Published on: November 10, 2016
Bent oligonucleotide duplexes as HMGB1 inhibitors: a comparative study
D Musumeci1, Giovanni N Roviello, M Moccia
1Istituto di Biostutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy. domymusu@alice.it
Abstract:
In this work we explore the ability of a chimeric LNA/DNA bent duplex, in which the kink is induced by 2 unpaired adenines in the middle of one strand, to bind HMGB1, a protein involved in many inflammatory processes. The LNA/DNA duplex was compared with the corresponding full DNA and PNA/DNA chimera duplexes from a thermodynamic and spectroscopic point of view.
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