Novel selective biocatalytic deacylation studies on key precursors for bicyclonucleosides
Ashok K Prasad1, Sunil K Singh, Neerja Kalra
1Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, India. ashokenzyme@yahoo.com
Abstract:
Immobilized Candida antarctica lipase and Thermomyces lanuginosus lipase catalyze the deacylation of precursors of LNA analogs, 4'-C-acyloxymethyl-2',3',5'-tri-O-acyl-beta-L-threo-pentofuranosylthymine and 4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-beta-L-threo-pentofuranose, respectively in a highly selective and efficient manner.
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