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Updated: Jul 9, 2026

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
Published on: July 20, 2016
Development of an antitumor adenosine analog, 3''-ethynyladenosine
Yoshio Endo1, Tohru Obata, Makoto Nomura
1Cancer Research Institute, Kanazawa University, Kanazawa, Japan. yendo@kenroku.kanazawa-u.ac.jp
Abstract:
3'-ethynyladenosine (EAdo) was an adenosine analog with potent antitumor activity against various human tumor cells in vitro. However, EAdo was enzymatically inactivated by adenosine deaminase (ADA) in vitro and in vivo. Therefore, we synthesized two ADA-resistant EAdo derivatives (2-F-EAdo and EAdo-5'-monophosphate, EAMP) and examined their antitumor activities.
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