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Published on: August 19, 2012
Study of different copper (I) catalysts for the "click chemistry" approach to carbanucleosides
Julie Broggi1, Nicolas Joubert, Vincent Aucagne
1Institut de Chimie Organique et Analytique, Université d'Orléans, Orléans, France.
Abstract:
We compare herein the scope of three copper (I) catalysts on the synthesis of various 1,4-disubstitued-1,2,3-triazolo-carbanucleosides through a microwave (and thermic) assisted Huisgen 1,3-dipolar cycloaddition. The tetrakis(acetonitrile)copper hexafluorophosphate ([Cu(CH3CN)4]PF6), the imidazoline(mesythyl)copper bromide (Imes)CuBr, and the copper/copper sulfate Cu(0)/CuSO4 (II) mixture have been chosen for this study. Their influence in a catalytic amount will be analyzed according to the substituent of the alkyne, the solvent, or the heating method.
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