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Updated: Jul 9, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
Regulatory T cells and tumour immunity - observations in mice and men
Awen Gallimore1, Andrew Godkin
1Medical Biochemistry and Immunology, Henry Wellcome Building, Heath Park, Cardiff University, Cardiff, CF14 4XN, UK. gallimoream@cf.ac.uk
Abstract:
An enormous body of work supports a role for CD4+ CD25+ regulatory cells (Tregs) in shaping the immune response to tumours. Indeed, there is evidence that the cells impede effective tumour immunosurveillance, inhibit vaccine-induced antitumour immune responses and promote tumour progression. Studies exploring the impact of Tregs on tumour development are discussed in the context of manipulating this T-cell population for the purpose of cancer immunotherapy.
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