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Related Concept Videos

Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Cross-reactivity00:42

Cross-reactivity

Overview
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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Related Experiment Video

Updated: Jul 9, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Type I interferon as a stimulus for cross-priming.

Agnès Le Bon1, David F Tough

  • 1INSERM U591 - Marie Curie Excellence Team, AVENIR Group, Faculté Necker, 156 rue de Vaugirard, 75015 Paris, France. lebon@necker.fr

Cytokine & Growth Factor Reviews
|December 11, 2007
PubMed
Summary
This summary is machine-generated.

Type I interferons (IFN-alpha/beta) are vital for innate immunity and also initiate adaptive immune responses. This review explores how IFN-alpha/beta drives CD8+ T cell immunity through cross-priming.

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Last Updated: Jul 9, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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Published on: March 24, 2015

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Published on: October 17, 2018

Area of Science:

  • Immunology
  • Infectious Disease
  • Cellular Biology

Background:

  • Type I interferons (IFN-alpha/beta) are critical innate immune mediators rapidly induced upon infection.
  • Beyond innate defense, IFN-alpha/beta plays a significant role in shaping adaptive immunity.
  • Cross-priming is a key mechanism for initiating T cell responses against pathogens.

Purpose of the Study:

  • To review the role of Type I interferons in adaptive immunity.
  • To elucidate the function of IFN-alpha/beta in CD8+ T cell priming.
  • To highlight the process of cross-presentation in T cell activation.

Main Methods:

  • Literature review of immunological studies.
  • Analysis of molecular mechanisms of interferon signaling.
  • Examination of T cell activation pathways.

Main Results:

  • IFN-alpha/beta is essential for the robust induction of CD8+ T cell responses.
  • Cross-priming by antigen-presenting cells is significantly enhanced by Type I interferons.
  • IFN-alpha/beta signaling promotes T cell proliferation and effector function.

Conclusions:

  • Type I interferons are crucial bridges between innate and adaptive immunity.
  • IFN-alpha/beta is indispensable for effective CD8+ T cell-mediated adaptive immunity via cross-priming.
  • Understanding this mechanism offers therapeutic potential for infectious diseases and cancer immunotherapy.