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NUP98-NSD1 fusion by insertion in acute myeloblastic leukemia
Arnaud Petit1, Isabelle Radford, Marie-Christine Waill
1National Institute of Health and Medical Research (INSERM), EMI 0210, Necker Pediatric Hospital, 149 rue de Sèvres, 75015 Paris, France.
Abstract:
A case of NUP98-NSD1 gene fusion resulting from the insertion of a subtelomeric part of chromosome 11p15.4 within the subtelomeric part of 5q35 was detected in a child with acute myeloblastic leukemia. This new case illustrates the importance of using fluorescence in situ hybridization followed by reverse transcriptase-polymerase chain reaction techniques to detect abnormalities involving subtelomeric chromosomal regions.
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