Increased S100B serum levels in dilated cardiomyopathy patients
Guilherme S Mazzini1, Débora V Schaf, Elsa R Vinadé
1Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, Brazil.
Journal of Cardiac Failure
|December 11, 2007
Summary
Serum S100B protein levels are elevated in dilated cardiomyopathy (DCM) patients. This study suggests the heart, not the brain, is the primary source of increased S100B in DCM, correlating with NT-proBNP levels.
Area of Science:
- Biochemistry
- Cardiology
- Biomarkers
Background:
- S100B protein is a known marker for brain injuries.
- Previous research indicated isolated rat hearts release S100B.
- The role of S100B in heart disease remained unclear.
Purpose of the Study:
- To investigate serum S100B levels in patients with dilated cardiomyopathy (DCM).
- To evaluate S100B as a potential cardiac marker in heart disease.
- To explore the correlation between S100B and NT-proBNP in DCM.
Main Methods:
- Selected DCM patients and age/sex-matched controls, excluding confounding conditions.
- Performed clinical evaluation and echocardiography for both groups.
- Measured serum S100B and NT-proBNP levels using established assays.
Main Results:
- DCM patients exhibited significantly higher serum S100B (0.051 µg/L vs 0.017 µg/L) and NT-proBNP (1462 pg/mL vs 35 pg/mL) compared to controls.
- A positive correlation was found between S100B and NT-proBNP serum levels exclusively in the DCM patient group (r=0.534, P=.013).
Conclusions:
- Elevated serum S100B in DCM patients suggests a cardiac origin.
- The positive correlation with NT-proBNP further supports the myocardium as the primary source of increased S100B.
- While brain S100B cannot be entirely excluded, cardiac contribution is significant in DCM.
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