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Updated: Jul 9, 2026
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
Thymic output and peripheral T lymphocyte subsets in relapsing--remitting multiple sclerosis patients treated or not
Bénédicte Puissant-Lubrano1, Frédérique Viala, Peter Winterton
1Laboratoire d'Immunogénétique Moléculaire, Université Paul Sabatier, Faculté de médecine Toulouse-Rangueil, Bâtiment A2, 133 Route de Narbonne, 31062 Toulouse cedex 4, France.
Abstract:
We explored the parameters of central and peripheral tolerance in patients with stable relapsing-remitting multiple sclerosis, treated or not with IFN-beta. TREC-positive T cells were lower in patients compared with controls, mainly in CD4+ subset, compatible with a thymus dysfunction or an expansion of peripheral lymphocytes. Compared to controls, the frequency of activated CD4+CD25+ T cells was higher in patients without modification of the CD4+CD25(high) T cell proportion. The IFN-beta-treatment did not modify the TREC-positive cell frequency nor the naive/memory T cell subset percentage but was associated with lower blood lymphocyte count and a lower frequency of CD4+CD45RC(high) subset.
