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Updated: Jul 9, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Unexplained polyarthralgia and celiac disease.
Karen Dawidowicz1, Hang-Korng Ea, Sophie Lahalle
1Rheumatology Federation, Lariboisière Teaching Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Joint Bone Spine
|December 11, 2007
Summary
Celiac disease, an immunological disorder, often presents with joint pain and anemia before gastrointestinal issues. Early diagnosis through antibody testing and biopsy is crucial to prevent complications like digestive cancers.
Area of Science:
- Immunology
- Gastroenterology
- Rheumatology
Background:
- Celiac disease is an immunological disorder primarily known for gastrointestinal symptoms.
- However, early joint manifestations are common and often overlooked features.
Observation:
- This case report details unexplained inflammatory polyarthralgia and iron-deficiency anemia leading to a celiac disease diagnosis.
- Autoimmune thyroiditis was also noted as a co-occurring condition.
Findings:
- Early diagnosis of celiac disease is vital for preventing severe complications, including digestive cancers.
- Serological tests for anti-gliadin, anti-endomysial, and anti-tissue transglutaminase antibodies offer rapid diagnostic tools.
- A duodenal biopsy remains the gold standard for definitive celiac disease diagnosis.
Implications:
- Recognizing non-gastrointestinal symptoms like joint pain can expedite celiac disease diagnosis.
- Prompt diagnosis and treatment mitigate risks of long-term complications.
- Integrating antibody screening into the workup for unexplained polyarthralgia and anemia is recommended.
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