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A comparative study on the genotoxic effect of pyrimethamine in bone marrow and spermatogonial mice cells

Scrap Celikler1, Nilüfer Aydemir, Rahmi Bilaloğlu

  • 1Uludag University, Science and Arts Faculty, Biology Department, 16059 Görükle, Bursa, Turkey. scelikler@uludag.edu.tr

Zeitschrift Fur Naturforschung. C, Journal of Biosciences
|December 12, 2007
PubMed

Insights

Pyrimethamine, an antimalarial drug, showed mutagenic potential by significantly increasing chromosomal aberrations in mouse bone marrow cells. It also induced abnormalities in spermatogonial cells at higher doses.

Area of Science:

  • Toxicology
  • Genetics
  • Pharmacology

Background:

  • Pyrimethamine is a widely used antimalarial drug in clinical settings.
  • Assessing the mutagenic potential of pharmaceuticals is crucial for patient safety.

Purpose of the Study:

  • To compare the mutagenic effects of pyrimethamine in mammalian spermatogonial and bone marrow cells.
  • To evaluate chromosomal aberrations induced by pyrimethamine treatment.

Main Methods:

  • Mice were administered single acute doses of pyrimethamine at 5, 10, 20, and 40 mg/kg.
  • Structural chromosomal aberrations were analyzed in bone marrow and spermatogonial cells.

Main Results:

  • Pyrimethamine significantly increased structural chromosomal aberrations in mouse bone marrow cells (p < 0.001).
  • Chromosome abnormalities were also observed in spermatogonial cells, particularly at the highest dose (p < 0.05).

Conclusions:

  • Pyrimethamine exhibits mutagenic potential in mammalian somatic and germ cells.
  • These findings highlight the importance of monitoring for genotoxicity during antimalarial therapy.

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