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[Bisphosphonates for myeloma patients]
1Department of Hematology, International Medical Center of Japan.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 12, 2007
Summary
Bisphosphonates (BPs) effectively reduce skeletal events in myeloma patients but can cause osteonecrosis of the jaw (ONJ). Good oral hygiene may prevent ONJ, a serious side effect impacting cancer therapy.
Area of Science:
- Oncology
- Pharmacology
Context:
- Bisphosphonates (BPs) are standard supportive care for multiple myeloma patients.
- They reduce skeletal-related events and offer direct/indirect anti-myeloma effects.
Purpose:
- To review the benefits and adverse events of bisphosphonates in multiple myeloma.
- To highlight the risk and potential prevention of osteonecrosis of the jaw (ONJ).
Summary:
- BPs demonstrate efficacy in decreasing skeletal events and possess anti-myeloma properties.
- Adverse events include flu-like syndrome and osteonecrosis of the jaw (ONJ).
- ONJ can necessitate treatment cessation and may be preventable with oral hygiene.
Impact:
- Understanding BP risks is crucial for myeloma patient management.
- Preventive strategies like oral hygiene can mitigate severe complications such as ONJ.
- This review informs clinical practice regarding BP use in multiple myeloma.
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