Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A random walk through a cannabis field.

R Mechoulam1, W A Devane, A Breuer

  • 1Hebrew University Medical Faculty, Jerusalem, Israel.

Pharmacology, Biochemistry, and Behavior
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unraveling the molecular basis of cannabidiolic acid methyl Ester's anti-depressive effects in a rat model of treatment-resistant depression.

Journal of psychiatric research·2024
Same author

The Long-Term Effect of a Quality Improvement Intervention in the Management of Bronchiolitis.

Indian pediatrics·2020
Same author

Long-Term Stability of Lorazepam in Sodium Chloride 0.9% Stored at Different Temperatures in Different Containers.

Hospital pharmacy·2020
Same author

Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression.

Behavioural brain research·2018
Same author

A robust variant of block Jacobi-Davidson for extracting a large number of eigenpairs: Application to grid-based real-space density functional theory.

The Journal of chemical physics·2017
Same author

Cannabis and epilepsy.

Epilepsy & behavior : E&B·2017

Cannabis research reveals high stereospecificity in cannabinoid action, challenging previous views. A new ligand offers a potent tool for studying cannabinoid receptors.

Area of Science:

  • Natural Products Chemistry
  • Pharmacology
  • Molecular Biology

Background:

  • Exploration of historical texts regarding cannabis terminology.
  • Investigation into the stereospecificity of cannabinoid receptor interactions.
  • Addressing discrepancies in previous research on cannabinoid activity.

Observation:

  • The term 'cannabis' may be absent from the Old Testament.
  • Stereospecificity of cannabinoid action is significantly higher than previously reported.
  • Enantiomeric impurities in tested samples likely skewed earlier findings.

Findings:

  • Purified (+)-enantiomers of Delta-1-THC, delta-6-THC, and 7-hydroxy-delta-6-THC show minimal activity (approx. 1%) compared to natural (-) enantiomers.
  • A novel labeled cannabinoid ligand, an equatorial C-1 epimer, was synthesized.

Related Experiment Videos

  • This new ligand exhibits high affinity for the cannabinoid receptor (Ki = 40 pM).

    • Implications:

    • Revises understanding of cannabinoid stereospecificity and receptor binding.
    • Highlights the critical role of sample purity in pharmacological studies.
    • The synthesized ligand is a valuable new tool for cannabinoid research and receptor studies.