Related Experiment Video
Updated: Jul 9, 2026
05:16
Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
Published on: February 19, 2022
Gastrointestinal sarcoidosis. A review
Matthew Adler1, Andrew Burroughs, Huw Beynon
1Department of Rheumatology, Royal Free Hospital, London, UK. matthew.adler@hwph-tr.nhs.uk
Summary
Gastrointestinal sarcoidosis is rare and often asymptomatic, complicating diagnosis. This review covers its manifestations, diagnostic challenges, and treatment options, including biologic therapies.
Area of Science:
- Gastroenterology
- Immunology
- Internal Medicine
Background:
- Sarcoidosis is a multisystem granulomatous disease.
- Gastrointestinal involvement is uncommon, often asymptomatic, but can cause significant morbidity and mortality.
- Hepatobiliary manifestations also occur.
Purpose of the Study:
- To review common and rare gastrointestinal and hepatobiliary manifestations of sarcoidosis.
- To discuss diagnostic difficulties and differential diagnoses.
- To outline treatment options, including novel therapies.
Main Methods:
- Comprehensive literature search of Pubmed from 1966 to 2006.
- Keywords: 'Gastrointestinal', 'Hepatobiliary', 'Sarcoidosis'.
Main Results:
- Review covers all sections of the gastrointestinal and hepatobiliary tracts.
- Highlights challenges in diagnosis due to asymptomatic nature and mimicry of other diseases.
- Discusses treatment strategies and disease associations.
Conclusions:
- Establishing a diagnosis of gastrointestinal sarcoidosis is challenging.
- Mimics other non-caseating granulomatous diseases.
- Biologic therapies show promise in managing sarcoidosis and associated biliary disorders.
Related Concept Videos
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
01:17Gastritis-II: Pathophysiology
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
01:26Gastritis II: Pathophysiology
The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
01:26Inflammatory Bowel Disease I: Introduction
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
01:12Giardiasis
Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
01:21Barrett Esophagus-II: Clinical Manifestations and Management
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...