Related Experiment Video
Updated: Jul 9, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
Published on: February 27, 2018
[Mechanisms of neuronal death in Huntington's disease. First part: general considerations and histopathological
1INSERM U837, Centre de Recherche Jean-Pierre Aubert, Université de Lille 2, IMPRT, Lille, France. Bantubungi@lille.inserm.fr
Abstract:
Huntington's disease is caused by an abnormal CAG expansion within the gene encoding Huntingtin which induces a major cortico-striatal degeneration as well as motor and cognitive impairments. Since the discovery of the present mutation, a number of experimental data have been collected to uncover the physiopathological consequences of mutated Huntingtin expression. Here, we review the molecular and cellular mechanisms underlying and show how this better knowledge can be translate to clinical trials in patients.
More Related Videos
10:52Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System
Published on: December 10, 2021
08:27Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
Published on: March 11, 2020
Related Concept Videos
Huntington Disease l: Introduction
Parkinson Disease ll: Pathophysiology
Alzheimer Disease ll: Pathophysiology
Parkinson Disease l: Introduction
Parkinson's Disease: Overview
Alzheimer Disease l: Introduction